Membrane-enriched acid-fast staining solution

Membrane-enriched acid-fast staining solution

Concentrate dispersed acid-fast bacilli onto the membrane surface so low-bacillary-load samples are easier to detect. A 4,114-sample clinical study reported 79.4% sensitivity for membrane-enriched smears versus 60.5% for direct smears.

Platform promise

Collect more. Lose less.

Membrane enrichment concentrates dispersed targets into a compact area and gives every downstream method a stronger starting sample.

Why it works

Why targets are easier to detect

Membrane enrichment retains dispersed cells, bacteria and small particles on a compact membrane surface. More target reaches the next step, while fewer elution, transfer and repeat-preparation operations mean fewer opportunities for low-abundance material to be lost.

Every avoided elution or transfer is one less opportunity to lose a low-abundance target.

Core advantages

  • Collect more: concentrate dispersed acid-fast bacilli onto a small membrane area

  • Cleaner background: reduce distracting debris for clearer fields

  • Connected workflow: automate slide preparation, staining and digital review

Applicable samples and scenarios

  • Sputum and other clinical samples listed in the product instructions

  • Low-bacillary-load acid-fast staining workflows

  • Batch workflows requiring automated slide preparation, staining and digital review

Workflow

  1. Sample preparation workflow illustration

    Step 1Sample pretreatment

    Sample preparation

    Prepare the sample according to the product instructions so targets are released into the enrichment workflow.

  2. Membrane-surface collection workflow illustration

    Step 2Enrichment

    Membrane-surface collection

    Use the sandwich cup and embedded-adsorption membrane to retain acid-fast bacilli at the surface while reducing loss from repeated transfers.

  3. Automated slide preparation and staining workflow illustration

    Step 3Staining

    Automated slide preparation and staining

    Move the enriched target directly into automated slide preparation and acid-fast staining for a uniform observation area.

  4. Microscopy and digital review workflow illustration

    Step 4AI-assisted review

    Microscopy and digital review

    Review manually or connect automated scanning and AI-assisted review for efficient batch processing.

Recommended product configuration

Data and research evidence

79.4%

Membrane-enriched smear sensitivity

In the same study, membrane-enriched smear sensitivity was 79.4% versus 60.5% for direct smears.

Tuberculosis 2022 original study

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Tell us your sample, target and current detection method. We will recommend the membrane route, consumables and workflow connection.

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